| 生物活性 |
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells. |
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| 体外研究 |
Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively. |
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| 分子式 |
C58H96O21
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| 分子量 |
1129.37
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| CAS号 |
194874-06-1
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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| 溶解性数据 |
DMSO : 1 mg/mL (0.89 mM; Need ultrasonic and warming) |
纯度： ≥95%
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Data Sheet
