Chlorin e6 - CAS:19660-77-6

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Chlorin e6 (Synonyms:二氢卟吩 E6; Ce6)

目录号 : KCM12322 CAS No. : 19660-77-6 纯度 : ≥98%

Data Sheet SDS 产品使用指南

Chlorin e6 (Ce6) is a photosensitizer. It is active against S. aureus, P. aeruginosa, E. coli, and S. typhimurium when used at a concentration of 20 µM in combination with photodynamic therapy (PDT). Ce6 (5 and 10 mg/kg) induces tumor regression when combined with PDT in several sarcoma rat xenograft models.

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50mg		In-stock
100mg		In-stock
250mg	询价	In-stock
500mg	询价	In-stock

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生物活性

Chlorin e6 is a photosensitizer and has strong absorption peaks at wavelength of 402 and 662 nm, as well as exhibiting intense fluorescence at 668 nm. Chlorin e6 has antimicrobial efficacy and anticancer activity. Chlorin e6 induces cell apoptosis via caspase-3 activation and can be used for the research of cancer.

体外研究

Chlorone6 (100 μg/mL, 24 h) showed no toxicity to HT-29 cells under 635 nm laser irradiation.
Chlorin e6 (5-10 μM, 3 h) induces apoptosis of pancreatic cancer cells by activating caspase-3 under 660 nm near-infrared laser irradiation, thereby inhibiting tumor growth of AsPC-1 and MIA PaCa-2 cells.

Western Blot Analysis

Cell Line:

AsPC-1 and MIA PaCa-2 Cells

Concentration:

5 μM, 10 μM

Incubation Time:

3 hour

Result:

Significantly reduced Bcl-2 protein expression while increasing apoptotic molecule expression of Bax.
Activated caspase-3 through its cleavage and upregulated the expression of cleaved PARP-1 in a dose-dependent manner.

体内研究

Chlorone6 (2.5 mg/kg, intravenous injection, single dose) exhibited anti-tumor activity in B16F10 melanoma cell and PANC02 pancreatic cell xenograft mouse models after 8 min and 20 s of red light irradiation at 100 J/cm2.
Chlorone6 (2.5 mg/kg, intravenous injection, single dose) can inhibit tumor growth in dogs under 660 nm near-infrared laser irradiation.

Animal Model:	B16F10 melanoma cells xenograft mouse, PANC02 pancreatic cells xenograft mouse
Dosage:	2.5 mg/kg
Administration:	Intravenous injection (i.v.)
Result:	Significantly reduced tumor volume.

分子式

C₃₄H₃₆N₄O₆

分子量

596.67

CAS号

19660-77-6

中文名称

二氢卟吩 E6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 20 mg/mL (33.52 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6760 mL	8.3798 mL	16.7597 mL
5 mM	0.3352 mL	1.6760 mL	3.3519 mL
10 mM	0.1676 mL	0.8380 mL	1.6760 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO → 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (3.49 mM); Suspended solution; Need ultrasonic

此⽅案可获得 2.08 mg/mL (3.49 mM) 的均匀悬浊液，悬浊液可⽤于⼝服和腹腔注射。

以 1 mL ⼯作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD ⽣理盐⽔⽔溶液中，混合均匀。