(±)14(15)-EET is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14(15)-EET may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14(15)-EET exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth.