1,2-Dimyristoyl-rac-glycerol - CAS:20255-94-1

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1,2-Dimyristoyl-rac-glycerol (Synonyms:1 2-二十四酰-rac-甘油;1,2-二肉豆蔻酸甘油酯;甘油1,2-二肉豆蔻酸酯)

目录号 : KCM12402 CAS No. : 20255-94-1 纯度 : ≥98%

Data Sheet 产品使用指南

1,2-Dimyristoyl-rac-glycerol is a diacylglycerol that contains myristic acid at the sn-1 and sn-2 positions. It increases phosphorylation of the insulin receptor in IM-9 cells when used at a concentration of 100 μg/ml. In vivo, 1,2-dimyristoyl-rac-glycerol (0.5 mg/kg) reduces tumor weight in an LY5178Y mouse xenograft model.

规格	价格	是否有货	数量
100mg		In-stock
250mg		In-stock
500mg		In-stock
10 mM * 1 mL in DMSO		In-stock

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生物活性

1,2-Dimyristoyl-rac-glycerol is a protein kinase C activator. 1,2-Dimyristoyl-rac-glycerol inhibits growth of lymphoblast solid tumors by enhancing endogenous glucocorticoid action, without increasing plasma corticosterone or ACTH levels. 1,2-Dimyristoyl-rac-glycerol can be used for the research of lymphoblast tumor.

体内研究

1,2-Dimyristoyl-rac-glycerol (15-120 μg/100 g body weight; Subcutaneous injection; Once a day; For 6 consecutive days, it can significantly inhibit the growth of L5178Y lymphoblastic tumor in normal mice by enhancing the effect of endogenous glucocorticoids, and does not affect mouse body weight or plasma corticosterone/ACTH levels at the tested dose.

Animal Model:

DBA/2 (male, 20-22 g, inoculated subcutaneously with 5×10⁶ L5178Y lymphoblast cells)

Dosage:

15 μg/100 g body weight; 30 μg/100 g body weight; 50 μg/100 g body weight; 75 μg/100 g body weight; 100 μg/100 g body weight

Administration:

s.c.; once daily; 6 days

Result:

Inhibited L5178Y lymphoblast tumor growth in a dose-dependent manner, with significant inhibition at tested doses.
Did not significantly alter plasma corticosterone or ACTH levels at 75 μg/100 g body weight, measured 1 hour and 24 hours after administration.
Did not cause significant changes in mouse body weight at tested doses.

分子式

C₃₁H₆₀O₅

分子量

512.81

CAS号

20255-94-1

中文名称

甘油1,2-二肉豆蔻酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 10 mg/mL (19.50 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9500 mL	9.7502 mL	19.5004 mL
5 mM	0.3900 mL	1.9500 mL	3.9001 mL
10 mM	0.1950 mL	0.9750 mL	1.9500 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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