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Dinactin , an antibiotic ionophore produced by Streptomyces species, as an effective small molecule targeting Wnt/β-catenin signaling pathway in cancer cells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC50 of 1.1 µM. Dinactin shows anti-proliferative activity against the cancer cells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain.

Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml for M.tuberculosis(ATCC 25177), S. epidermidis(ATCC 12228), M. luteus(ATCC10240), S. aureus(ATCC 35923), E. faecalis(ATCC 51299), B. subtilis(ATCC 11774), E. coli(ATCC 10536), P. aeruginosa(ATCC 10145), K. pneumonia(ATCC BAA-2146) strain, respectively.
Dinactin (0-100 µM) shows antitumor activity with IC₅₀ values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 µM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively.
Dinactin (0.5, 1, 2 µM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells.
inactin (0.5, 1, 2 µM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells.