KKL 顾客使用本产品发表的 0 篇科研文献

GLP-1R Agonist DMB  is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R. GLP-1R Agonist DMB has the potential for research in metabolic diseases such as type 2 diabetes and obesity.

GLP-1R Agonist DMB (100 nM, 1000 nM) can activate GLP-1 receptor-mediated cAMP production, with an EC₅₀ of 101 nM, but exhibits a self limiting effect at high concentrations .

GLP-1R Agonist DMB (100 nM) enhances the binding of GLP-1 to GLP-1 receptors and reduces the K_d value of GLP-1 (from 0.51 nM to 0.19 nM).

GLP-1R Agonist DMB (100 nM, 1000 nM) promotes glucose dependent insulin secretion in CD1 mouse islets, and this effect depends on the GLP-1 receptor. At concentrations of 100 nM and 1000 nM, GLP-1R Agonist DMB significantly enhances 10 mM glucose induced insulin secretion, similar to GLP-1, and this effect disappears in the islets of GLP-1 receptor knockout mice.

Room temperature in continental US; may vary elsewhere.

2-8°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)