4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside - CAS:37067-30-4

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4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-Glucopyranoside (Synonyms:4-甲基香豆素-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷;(4-甲基伞形酮)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷;4-甲基N-乙酰基β-D-葡糖苷;4-甲基伞形酮 2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷;4-甲基伞形酮-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖苷;4-甲基伞形酮-N-乙酰-β-D-氨基葡糖苷 (氟代五氯丙酮);4-甲基伞形酮-β-N-乙酰基-D-氨基葡萄糖苷;4-甲基伞形酯-n-乙酰氨基-beta-D-葡萄糖;氟代五氯丙酮;4-甲基伞形酮基-2-乙酰氨基-2-脱;4-甲基伞形酮基2-乙酰氨基-2-脱氧-β4-甲基伞形酮基-N-乙酰-β-D-氨基葡糖苷;4-甲基伞形酮酰-N-乙酰-β-D-;small>-吡喃葡萄糖苷;美金刚胺盐酸盐;4-甲基伞形酮基N-乙酰基-Β-D-氨基葡糖苷;4-甲基香豆素-2-乙酰氨基-2-脱氧-beta-D-吡喃葡萄糖苷)

目录号 : KCM13577 CAS No. : 37067-30-4 纯度 : ≥98%

Data Sheet SDS 产品使用指南

4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside is a fluorogenic substrate for β-hexosaminidases. Upon enzymatic cleavage by β-hexosaminidases, 4-methylumbelliferone (4-ΜU) is released and its fluorescence can be used to quantify β-hexosaminidase activity. 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-2-acetamido-2-deoxy-β-D-glucopyranoside has been used to quantify β-hexosaminidase activity in serum or leukocytes from patients with G gangliosidoses such as Tay-Sachs disease, which is characterized by defects in the α subunit of β-hexosaminidase.