4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (sodium salt)
(Synonyms:4-甲基香豆素-2-磺胺-2-去氧基-α-D-葡糖苷酸钠盐;D-罗通定;7-[[2-脱氧-2-(磺基氨基)-alpha-D-吡喃葡萄糖基]氧基]-4-甲基-2H-1-苯并吡喃-2-酮单钠盐)
目录号 : KCM13862
CAS No. : 460085-45-4
纯度 : ≥98%
4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase. Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm. The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively. 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.
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| 分子式 |
C16H18NO10S.Na
|
| 分子量 |
416.38086
|
| CAS号 |
460085-45-4
|
| 中文名称 |
D-罗通定
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|