Isoxanthohumol
(Synonyms:异黄腐酚;4',7-二羟基-5-甲氧基-8-(3-甲基-2-丁烯基)黄烷酮)
目录号 : KCM14086
CAS No. : 521-48-2
纯度 : ≥98%
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (ICs = 22.15 and 22.9 µM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits K1.3 channels with an EC value of 7.8 µM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.
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| 分子式 |
C21H22O5
|
| 分子量 |
354.4
|
| CAS号 |
521-48-2
|
| 中文名称 |
4',7-二羟基-5-甲氧基-8-(3-甲基-2-丁烯基)黄烷酮
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|