L-Leucyl-L-Leucine methyl ester (hydrochloride)
(Synonyms:L-亮氨酰-L-亮氨酸甲酯盐酸盐)
目录号 : KCM14708
CAS No. : 6491-83-4
纯度 : ≥95%
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4 and CD8 T lymphocytes without affecting helper T cells and B cells. It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells.
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| 分子式 |
C13H26N2O3.HCl
|
| 分子量 |
258.34
|
| CAS号 |
6491-83-4
|
| 中文名称 |
L-亮氨酰-L-亮氨酸甲酯盐酸盐
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|