ATN-224
(Synonyms:四硫钼酸二胆碱)
目录号 : KCM14714
CAS No. : 649749-10-0
纯度 : ≥95%
ATN-224 is a choline salt of tetrathiomolybdate and an inhibitor of superoxide dismutase 1 (SOD1; ICs = 2.91 and 3.51 µM in human and mouse blood cells, respectively, in vitro). ATN-224 reduces the viability of cultured oxidative stress-resistant WEHI7.2 murine thymic lymphoma cells (ECs = 5-6 nM) and human diffuse large B cell lymphoma cell lines (ECs = 9.73-105.61 nM) independently of Bcl-2 and Bcl-xL. In vivo, ATN-224 (0.7 mg/kg) chelates copper to stabilize an antitumor viral vector, enhancing its efficacy against lung metastases in mice. It also inhibits angiogenesis in a mouse model (ICs = 1.50-3 mg/kg via gavage).
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| 分子式 |
C5H14NO.1/2MoS4
|
| 分子量 |
432.5
|
| CAS号 |
649749-10-0
|
| 中文名称 |
四硫钼酸二胆碱
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|