5'-deoxy-5-Fluorocytidine
(Synonyms:5'-脱氧-5-氟胞嘧啶核苷;5'-脱氧-5-氟胞苷;5'-去氧氟胞苷;5´-脱氧-5-氟胞苷;5''-脱氧-5-氟胞苷;5’-脱氧-5-氟胞苷;5'-Deoxy-5-fluorocytidine 5'-脱氧-5-氟胞嘧啶核苷;5'-DFCR(5'-脱氧-5-氟胞苷);5鈥?-Deoxy-5-fluorocytidine;5-脱氧-5-氟胞苷;5''-脱氧-5-氟胞嘧啶核苷;卡培他滨相关化合物A;卡培他滨相关物质A;卡培他滨杂质1;卡培他滨杂质A;卡培他滨 USP杂质A;卡培他滨相关杂质A;5'-脱氧-5-氟胞啶)
目录号 : KCM14755
CAS No. : 66335-38-4
纯度 : ≥98%
5'-deoxy-5-Fluorocytidine is an intermediate metabolite of the DNA synthesis inhibitor capecitabine . Capecitabine is converted by carboxylesterase to 5'-deoxy-5-fluorocytidine in the liver, then by cytidine deaminase to 5’-deoxy-5-fluorouridine in the liver and tumor tissues, and finally, by thymidine phosphorylase to 5-fluorouracil in tumors. The cytotoxicity of this intermediate occurs only after conversion to 5-fluorouracil.
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| 分子式 |
C9H12FN3O4
|
| 分子量 |
245.2
|
| CAS号 |
66335-38-4
|
| 中文名称 |
5'-脱氧-5-氟胞嘧啶核苷
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|