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Apatinib (Synonyms:Apatinib 抑制剂;N-[4-(1-氰基环戊基)苯基]-2-[(4-吡啶基甲基)氨基]-3-吡啶甲酰胺;阿帕替尼Apatinib (YN968D1);甲磺酸阿帕替尼;普罗帕酮)
目录号 : KCM15309 CAS No. : 811803-05-1 纯度 : ≥98%
Data Sheet SDS 产品使用指南
Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC = 1 nM). It is less effective against c-kit (IC = 429 nM), Ret (IC = 13 nM), and c-src (IC = 53 nM) and does not inhibit EGFR, Her-2, or FGFR1 (ICs = >10 µM). Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells stimulated by fetal bovine serum and, either alone, or in combination with chemotherapeutic agents, prevented the growth of several established human tumor xenograft models.
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分子式
C24H23N5O
分子量
397.5
CAS号
811803-05-1
中文名称
阿帕替尼
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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