NIAD-4 - CAS:868592-56-7

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NIAD-4

目录号 : KCM15514 CAS No. : 868592-56-7 纯度 : ≥98%

Data Sheet 产品使用指南

NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-β (Aβ) plaques (K = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red emission occurring upon binding to Aβ.

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
10 mM * 1 mL in DMSO		In-stock

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生物活性

NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM.

体外研究

NIAD-4 can bind to amyloid protein aggregates, hindering their internal rotation and increasing fluorescence yield and intensity, making it an effective tool for detecting amyloid protein. NIAD-4 can cross the brain barrier and, due to its neutral charge and low molecular weight, can be used for imaging amyloid fibrils in the brain. The excitation wavelength of NIAD-4 is 475 nM, and the emission wavelength is 610 nM.

分子式

C₁₈H₁₀N₂Os₂

分子量

334.4

CAS号

868592-56-7

中文名称

2-((5'-(4-hydroxyphenyl)-2,2'-bithiophen-5-yl)methylene)malononitrile

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO: 25 mg/mL (74.75 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9902 mL	14.9508 mL	29.9016 mL
5 mM	0.5980 mL	2.9902 mL	5.9803 mL
10 mM	0.2990 mL	1.4951 mL	2.9902 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%