Pembrolizumab (MK-3475)是一种抑制 PD-1 受体的人源化单克隆抗体，是一个 HER2 二聚化抑制剂类，它会削弱 HER2 与 HER 家族其他成员结合的能力。
| 生物活性 |
Pembrolizumab (MK-3475) is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the HER family. |
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| 体外研究 |
Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells. |
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| 体内研究 |
Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure. |
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| 分子式 |
N/A
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| 分子量 |
145.24 kDa
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| CAS号 |
1374853-91-4
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| 中文名称 |
派姆单抗
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| 储存方式 |
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