Dimethyl 2-ketoglutarate - CAS:13192-04-6

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Dimethyl 2-ketoglutarate (Synonyms:alpha-酮戊二酸二甲酯)

目录号 : KG10553 CAS No. : 13192-04-6 纯度 : >95%

Data Sheet 产品使用指南

Dimethyl 2-ketoglutarate is an esterified form of the citric acid cycle intermediate α-ketoglutarate. It increases intracellular levels of α-ketoglutarate and decreases intracellular ATP levels in U2OS human osteosarcoma cells cultured in complete- or nutrient-free media when used at a concentration of 5 mM. Dimethyl 2-ketoglutarate inhibits autophagy and decreases in intracellular levels of acetyl-CoA in serum- and nutrient-deprived cells. It decreases cardiomyocyte hypertrophy in a mouse model of cardiac pressure overload induced by thoracic aortic constriction when administered at a dose of 300 mg/kg. Dimethyl 2-ketoglutarate reduces serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and hepatic fibrosis in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4).

规格	价格	是否有货	数量
5g		In-stock	立即试用

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分子式

C₇H₁₀O₅

分子量

174.2

CAS号

13192-04-6

中文名称

alpha-酮戊二酸二甲酯

储存方式

-20°C

溶解性数据

In Vitro:

H2O : 100 mg/mL (574.22 mM; Need ultrasonic)

DMSO : 100 mg/mL (574.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.7422 mL	28.7109 mL	57.4218 mL
5 mM	1.1484 mL	5.7422 mL	11.4844 mL
10 mM	0.5742 mL	2.8711 mL	5.7422 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：PBS

Solubility: 100 mg/mL (574.22 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂：0.5% CMC/saline water

Solubility: ≥ 50 mg/mL (287.11 mM); Clear solution
3.

请依序添加每种溶剂： 50% PEG300 → 50% PBS

Solubility: ≥ 50 mg/mL (287.11 mM); Clear solution