SH-42 是一种有效和选择性的人Δ24-脱氢胆固醇还原酶 (DHCR24) 抑制剂，IC50 值为 42 nM。SH-42 可导致小鼠血浆去甾醇水平显着增加。
| 生物活性 |
SH-42 is an inhibitor of ∆24-dehydrocholesterol reductase (DHCR24; IC50 = 4.2 nM). It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A . SH-42 (0.5 mg/animal three times per week) decreases disease severity in mice expressing liver X receptor α (LXRα-positive) but not LXRα-deficient mice in a model of hepatic steatosis induced by a high-fat high-cholesterol diet. |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子式 |
C25H38O4
|
||||||||||||
| 分子量 |
402.6
|
||||||||||||
| CAS号 |
2143952-36-5
|
||||||||||||
| 储存方式 |
|
纯度： >95%
咨询热线：
400-881-9290
Data Sheet
