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PF-562271 HCl (Synonyms:N-甲基-N-(3-{[2-(2-氧代-2,3-二氢-1H-吲哚-5-基氨基)-5-三氟甲基-嘧啶-4-基氨基]-甲基}-吡啶-2-基)-甲烷磺酰胺)
目录号 : KG10823 CAS No. : 939791-41-0 纯度 : 98%
Data Sheet 产品使用指南
PF-562271 is a potent, ATP-competitive and reversible inhibitor of both focal adhesion kinase (FAK), a non-receptor tyrosine kinase involved in a variety of cellular events, and proline-rich tyrosine kinase 2 (Pyk2), an FAK homolog containing 48% amino acid identity, with half maximal inhibitory concentration (IC50) of 1.5 nmol/L and 14 nmol/L respectively. As a potential therapeutic agent either alone or in combination with other agents for the treatment of cancer, PF-562271 has been reported to effectively inhibit the proliferation of tumors in both xenograft and transgenic mouse models, in which it dose-dependently inhibits FAK phosphorylation in tumor-bearing mice with half maximal effective concentration (EC50) of 93 ng/mL.
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分子式
C21H21ClF3N7O3S
分子量
543.95
CAS号
939791-41-0
中文名称
PF-562271 HCl
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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