Sinigrin (hydrate)
(Synonyms:芥子苷单水合物;黑芥子硫苷酸钾一水;白芥子提取物;黑介子苷;黑介子苷,Sinigrin;黑介子苷,Sinigrin,植物提取物,标准品,对照品;黑介子硫苷酸钾;黑芥子苷;黑芥子硫苷酸钾一水 标准品;黑芥子硫苷酸钾一水对照品;芥子甙单水合物;一水合黑芥子硫苷酸钾;黑芥子硫苷酸钾一水物)
目录号 : KG11227
CAS No. : 64550-88-5
纯度 : >95%
Sinigrin is a glucosinolate that has been found in Brassica and has diverse biological activities. It inhibits NOD-like receptor protein 3 (NLRP3) inflammasome activation in ATP-stimulated, LPS-primed RAW 264.7 cells in a concentration-dependent manner. Sinigrin (1-100 µg/ml) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 , as well as NF-κB activation, in RAW 264.7 cells. It induces cell cycle arrest at the G0/G1 phase in HepG2 hepatocellular carcinoma cells when used at concentrations of 0.1 and 0.5 mM.2 Sinigrin (10 and 20 mg/kg) reduces increases in renal glomerular basement membrane thickness, as well as increases in systolic and diastolic blood pressure, in a rat model of hypertension induced by angiotensin II.
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| 分子式 |
C10H16NO9S2.K[XH2O]
|
| 分子量 |
397.5
|
| CAS号 |
64550-88-5
|
| 中文名称 |
一水合黑芥子硫苷酸钾
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|