Aminopterin (4-Aminofolic acid)，叶酸的 4-氨基衍生物，是叶酸 (folic acid) 拮抗剂。Aminopterin 催化叶酸还原为四氢叶酸，Aminopterin 竞争性抑制二氢叶酸还原酶 (DHFR)，Ki 值为 3.7 pM。Aminopterin 具有抗癌和免疫抑制活性。Aminopterin 用于研究儿童白血病。
| 生物活性 |
Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia. |
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| 体外研究 |
The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM. |
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| 分子式 |
C19H20N8O5
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| 分子量 |
440.41
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| CAS号 |
54-62-6
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| 中文名称 |
氨基蝶呤
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : 14.71 mg/mL (33.40 mM; Need ultrasonic) H2O : 5 mg/mL (11.35 mM; ultrasonic and adjust pH to 8 with NaOH) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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