SUN B8155 是降钙素 (calcitonin) 受体的非肽激动剂，选择性地模拟降钙素的生物作用。降钙素是一种主要由甲状腺分泌的 32 个氨基酸的肽激素，在维持骨内稳态方面起着重要作用。
| 生物活性 |
SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis. |
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| 体外研究 |
SUN B8155 (1-1000 μM; 1 hour) stimulates intracellular cAMP formation in T47D cells in a concentration-dependent manner; the concentration of synthesized cAMP increased by approximately 42-fold at the highest concentration. SUN B8155 also stimulates cAMP formation in the rat osteogenic sarcoma-derived cell line, UMR106-06. |
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| 体内研究 |
SUN B8155 (100 mg/kg; i.p.) results in a significant reduction of serum calcium concentration by approximately 9% at 30 min after administration. Human CT also reduces serum calcium in a dose-dependent manner at 30 min (0.1 and 0.3 μg/kg) and 60 min (0.3 μg/kg) after administration. |
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| 分子式 |
C14H15N3O3
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| 分子量 |
273.29
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| CAS号 |
345893-91-6
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| 中文名称 |
SUNB8155
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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