PF 9601N
(Synonyms:5-苄氧基-N-2-丙炔-1-基-1H-吲哚-2-甲胺)
目录号 : KG12521
CAS No. : 133845-63-3
纯度 : 98%
PF 9601N is an inhibitor of monoamine oxidase B (MAO-B). It selectively inhibits MAO-B in mouse brain homogenates ex vivo (ID50 = 381 nmol/kg) and prevents MPTP-induced reductions in dopamine levels in the striatum of 8- to 9-week-old mice when administered at doses ranging from 29.5 to 8.47 µmol/kg. PF 9601N (0.027 µmol/kg) prevents MPTP-induced lesions in 9- to 10-month-old mice. It also increases the duration of contralateral rotational behavior induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA when administered at doses of 40 and 60 mg/kg.
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| 分子式 |
C19H18N2O
|
| 分子量 |
290.4
|
| CAS号 |
133845-63-3
|
| 中文名称 |
PF 9601N
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|