| 生物活性 |
AChE-IN-6 (Compound 12a) is an optimal multifunctional ligand with significant inhibition of AChE (EeAChE, IC50 = 0.20 μM; HuAChE, IC50 = 37.02 nM) and anti-Aβ activity (IC50 = 1.92 μM for self-induced Aβ1-42 aggregation; IC50 = 1.80 μM for disaggregation of Aβ1-42 fibrils; IC50 = 2.18 μM for Cu2+-induced Aβ1-42 aggregation; IC50 = 1.17 μM for disaggregation of Cu2+-induced Aβ1-42 fibrils). AChE-IN-6 has the potential for the research of Alzheimer's disease.
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| 分子式 |
C29H41N5O2
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| 分子量 |
491.67
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| CAS号 |
2758788-95-1
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| 中文名称 |
化合物 AChE-IN-6
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： 98%
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Data Sheet
