Daltroban - CAS:79094-20-5

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Daltroban (Synonyms:BM-13505; SKF 96148)

目录号 : KM8818 CAS No. : 79094-20-5 纯度 : 98%

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Daltroban (BM-13505) 是一种选择性和特异性血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 增加血管平滑肌细胞内钙。Daltroban 对再灌注损伤有保护作用。

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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生物活性

Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury.

体内研究

Daltroban (BM-13505) (1 mg/kg; i.v.; per hour) exerts protective effect in reperfusion injury following acute myocardial ischemia in cats.
In comparison with vehicle (physiological saline)-treated cats, Daltroban (20 mg/kg per hour i.v.) reduces the ischaemia-induced rise in the ST segment and prevented the development of a Q-wave in the ECG during reperfusion. Daltroban protects the myocardium from ischaemic injury and that this effect involves prevention of ischaemia-induced leukocytosis.

Animal Model:	Adult male cats (2.8 to 4.6 kg; anesthetized cat model)
Dosage:	1 mg/kg
Administration:	i.v.; 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hour
Result:	Significantly reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics and thereby not influencing myocardial oxygen demand.

分子式

C₁₆H₁₆NO₄Scl

分子量

353.82

CAS号

79094-20-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度： 98%

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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