Thalidomide-NH-CH2-COOH TFA 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。
| 生物活性 |
Thalidomide-NH-CH2-COOH TFA is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH TFA can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032. |
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| 体外研究 |
PROTAC contains two different ligands connected by a linker; One is the ligand for E3 ubiquitin ligase, and the other is the ligand for the target protein. PROTAC utilizes the intracellular ubiquitin proteasome system to selectively degrade target proteins. |
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| 分子式 |
C17H14F3N3O8
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| 分子量 |
445.307
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| CAS号 |
2377032-39-6
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| 中文名称 |
2-[[2-(2,6- 二氧代哌啶-3-基)-1,3-二氧代异吲哚-4-基]氨基]乙酸 2,2,2-三氟乙酸
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： ≥95%
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Data Sheet
