Ipamorelin是一种五肽（Aib-His-D-2-Nal-D-Phe-Lys-NH2），也是一种具有生长激素（GH）释放活性的胃泌素模拟物。Ipamorelin模仿胃泌素并与大脑中的胃泌素受体（或生长激素分泌受体，GHSR）结合，从而选择性地刺激垂体释放生长激素。这会导致血浆 GH 水平升高，从而影响许多生物过程。除了存在于大脑中，GHSR 还存在于胃肠道、心脏、肺、肝脏、肾脏、胰腺、脂肪组织和免疫细胞中。与其他促生长激素释放肽不同，ipamorelin 只以与生长激素释放激素非常相似的方式刺激促生长激素的释放。
| 生物活性 |
Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) and a ghrelin mimetic with growth hormone (GH) releasing activity. Ipamorelin mimics ghrelin and binds to the ghrelin receptor (or GH secretagogue receptor, GHSR) in the brain, thereby selectively stimulating the release of GH from the pituitary gland. This results in increased plasma GH levels, which would affect many biological processes. Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells. Unlike other GH releasing peptides, ipamorelin only stimulates GH release in a manner very similar to that of growth hormone releasing hormone. |
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| 分子式 |
C38H49N9O5
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| 分子量 |
711.8530
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| CAS号 |
170851-70-4
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| 中文名称 |
伊帕瑞林
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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