| 生物活性 |
o-Anisidine is an orally active phenol compound and can interact with amyloid-beta (Aβ1-40) wild-type, Iowa-mutant D23N and Osaka-mutant ΔE22. o-Anisidine can bind to Aβ1-40 Leu34 via hydrogen bonding. o-Anisidine induces formation of γ-H2AX, a biomarker of DNA damage. o-Anisidine causes gradual development of simple hyperplasia of rat urinary bladder urothelium with slight inflammation. o-Anisidine can be used for the researches of Alzheimer's disease and bladder cancer. |
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| 体外研究 |
o-Anisidine can interact with wild-type Aβ1-40, the Iowa mutant D23N, and the Osaka mutant ΔE22, with Ki values of 3.67, 7.5, and 4.29 mM, respectively. |
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| 体内研究 |
O-Anisidine (0.3-1.0%; oral; Dietary administration; Daily; 4 weeks) can induce time-dependent simple hyperplasia and persistent γ - H2AX formation in rat bladder epithelium, suggesting that there is DNA damage that may be related to bladder cancer.
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| 分子式 |
C7H9NO
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| 分子量 |
123.15
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| CAS号 |
90-04-0
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| 中文名称 |
邻氨基苯甲醚
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
2-8°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Data Sheet
