DSPE-PEG2000-RVG29 - KKL Med Inc.

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DSPE-PEG2000-RVG29

目录号 : KM32788 纯度 : 95%

Data Sheet 产品使用指南

DSPE-PEG2000-RVG29 是一种由 DSPE 与狂犬病病毒糖蛋白29（RVG29）通过 PEG 链连接而成的化合物。RVG29 能够特异性结合血脑屏障（BBB）处的烟碱乙酰胆碱受体（nAChR），不仅能穿过 BBB，还可介导受体依赖性的转胞吞作用。因此，该化合物可应用于脑部靶向药物递送、纳米载体表面修饰以及基因与核酸递送，并在缺氧缺血性脑损伤和帕金森病等相关研究中具有应用价值。

规格	价格	是否有货	数量
5mg		In-stock

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Other Forms of Rapamycin:

DSPE-PEG2000-RVG29 In-stock
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生物活性	DSPE-PEG2000-RVG29 is a PEG conjugate composed of DSPE and rabies virus glycoprotein 29 (RVG29). RVG29 specifically binds to nicotinic acetylcholine receptors (nAChR) at the blood-brain barrier (BBB), crosses the BBB, and mediates receptor-dependent transcytosis. DSPE-PEG2000-RVG29 can be used for brain-targeted drug delivery, surface modification of nanocarriers, as well as gene and nucleic acid delivery. DSPE-PEG2000-RVG29 is applicable to research related to hypoxic-ischemic brain injury, Parkinson's disease, and other conditions.
体外研究	DSPE-PEG2000-RVG29 modified M-R@siC-NPs It has a uniform particle size distribution, near neutral surface charge, efficient siRNA loading capacity, and long-term structural stability in biological media. DSPE-PEG2000-RVG29-containing M-R@siC-NPs (20-120 μg/mL; 24 h) exhibits low cytotoxicity in primary astrocytes, with no significant toxicity at concentrations up to 80 μ g/mL, but cell survival rate decreases at higher doses. DSPE-PEG2000-RVG29-functionalized BAELPP (0.5 μg DNA equivalent per well; High transfection efficiency and low cytotoxicity were achieved in human neuroblastoma SH-SY5Y cells at 24 h/48 h.
体内研究	M-R@siC-NPs (including DSPE-PEG2000-RVG29) (80 μg/mL; intraperitoneal injection) can effectively inhibit the activation of hippocampal astrocytes in HIBD neonatal mice, alleviate neuroinflammation, and improve their motor coordination and spatial memory. DSPE-PEG2000-RVG29 (10 mol%; orbital injection) modification can enhance the brain targeting of lipid polymer complexes, thereby achieving upregulation and regional distribution of transgenic expression in the striatum and substantia nigra of mice.
分子量	2000 (Average)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)