3,6-DMAD hydrochloride是未折叠蛋白质应答 (IRE1α-XBP1) 通路的抑制剂。
| 生物活性 |
3,6-DMAD hydrochloride is a inhibitor of the IRE1α-XBP1 pathway of the unfolded protein response. |
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| 体外研究 |
3,6-DMAD inhibits both IRE1α oligomerization and in vitro endoribonuclease (RNase) activity. |
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| 体内研究 |
Following three intraperitoneal administrations of 3,6-DMAD at a dose of 10 mg/kg every 12 hours, 3,6-DMAD significantly inhibits in vivo XBP1-luciferase activity assessed 3.5 days after the initial treatment. 3,6-DMAD-treatment significantly inhibits tumor xenograft growth.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : 25 mg/mL (Need ultrasonic) |
纯度： 98%
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Data Sheet
