Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
体外研究
CRF increases excitability of type II dlBNST neurons through activation of the AC-cAMP-PKA pathway, thereby causing pain-induced aversive responses.
体内研究
In rats injected with CRF (1 nmol/side), the time spent in the drug-paired compartment during the test session (314±22 s) is significantly shorter than time spent in that compartment during the preconditioning session (520±18 s).
分子式
C208H343N59O64S2
分子量
4757.45
CAS号
86784-80-7
中文名称
促肾上腺皮质激素释放因子 (人)
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder
-80°C
2 years
-20°C
1 year
In solvent
-80°C
6 months
-20°C
1 month
溶解性数据
In Vitro:
H2O : 16.66 mg/mL (3.50 mM; Need ultrasonic and warming)