3-Hydroxyisobutyrate (sodium salt) - CAS:1219589-99-7

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3-Hydroxyisobutyrate (sodium salt) (Synonyms:3-羟基-2-甲基-丙酸钠盐)

目录号 : KCM10710 CAS No. : 1219589-99-7 纯度 : ≥95%

Data Sheet 产品使用指南

3-Hydroxyisobutyrate (3-HIB) is an intermediate in the metabolism of the branched-chain amino acid valine that is secreted by skeletal muscle. It dose-dependently increases fatty acid uptake by human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 0.1 to 100 mM. 3-HIB also increases fatty acid uptake and lipid accumulation in mouse skeletal muscle when administered in drinking water. The levels of 3-HIB in muscle are increased in db/db diabetic mice and in humans with diabetes. Human plasma levels are increased in obesity and correlate with a future risk of type 2 diabetes. In addition, human serum levels of 3-HIB decrease by 2.5-fold immediately following an exercise regimen of 2.5 hours of running for three days.

规格	价格	是否有货	数量
250mg		In-stock
1g		In-stock

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生物活性

3-Hydroxyisobutyrate (sodium salt) is an intermediate in the metabolic pathways of L-valine and thymine, and can be found in urine. 3-Hydroxyisobutyrate (sodium salt) is a secreted mediator of endothelial cell fatty acid transport and insulin resistance. 3-Hydroxyisobutyrate (sodium salt) can also inhibit key enzymes of energy metabolism in the cerebral cortex of young rats. The levels of 3-Hydroxyisobutyric acid sodium are closely related to various diseases such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis.

体外研究

3-Hydroxyisobutyric acid (0.1-1 mM) sodium significantly inhibits respiratory chain complex I-III activity, total creatine kinase and mitochondrial creatine kinase activity, as well as Na+, K+- ATPase activity in the white layer homogenate of the brain.

分子式

C₄H₇O₃^.Na

分子量

126.09

CAS号

1219589-99-7

中文名称

3-Hydroxy-2-methylpropionic acid sodium

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H2O : 100 mg/mL (793.08 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	7.9308 mL	39.6542 mL	79.3084 mL
5 mM	1.5862 mL	7.9308 mL	15.8617 mL
10 mM	0.7931 mL	3.9654 mL	7.9308 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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