(±)-Anatoxin A is a bicyclic amine isolated from the blue-green alga A. aquae that displays high affinity for nicotinic acetylcholine receptors (K = 0.1-0.2 μM). It binds α4β2- and α7-type nicotinic receptors with K values of 1.3 nM and 1.8 μM, respectively, and stimulates [H]-dopamine release from striatal synaptosomes with an EC value of 134 nM.
(±)-Anatoxin A (fumarate) is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A (fumarate) is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to α4β2- and α7-type nicotinic receptors in rat brain membranes, respectively. (±)-Anatoxin A (fumarate) stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM). (±)-Anatoxin A (fumarate) has toxic effect on fish.
分子式
C10H15NO.C4H4O4
分子量
281.3
CAS号
1219922-30-1
中文名称
消旋类毒素A富马酸盐
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
2-8°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)