| 生物活性 |
AG-213 is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). AG-213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). TAG-213 can induce nonapoptotic cell programmed death in tumor cells, |
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| 体外研究 |
AG-213 (25 μM, 50 μM, and 75 μM; 24 h, 48 h, and 96 h) increases wound closure time in human umbilical vein endothelial cell (HUVEC) monolayer. AG-213 (100 μM; 1 h) interferes with HUVEC focal adhesion and stress fiber formation. AG-213 (100 μM; 24 h) inhibits adherence-related tyrosine phosphorylation of pp125FAK in HUVEC. AG-213 (10 μM; 24 h) inhibits tyrosine kinase activity, and (4.55-455 mM; 24-72 h) inhibits HT-29 cell viability doseand time-dependently. |
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| 分子式 |
C10H8N2O2S
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| 分子量 |
220.2
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| CAS号 |
122520-86-9
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| 中文名称 |
酪氨酸磷酸化抑制剂A47
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： ≥97%
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