ON-01910 (sodium salt) - CAS:1225497-78-8

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ON-01910 (sodium salt) (Synonyms:N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐;Rigosertib (ON-01910) 抑制剂;ON 01910 钠盐)

目录号 : KCM10740 CAS No. : 1225497-78-8 纯度 : ≥98%

Data Sheet 产品使用指南

ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling. It induces apoptosis in a wide array of tumor cell lines (GI = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines. ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock

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生物活性

ON-01910 (sodium salt) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

体外研究

ON-01910 (sodium salt) is a non ATP competitive PLK1 inhibitor with an IC50 of 9 nM, which is 30 times more selective than Plk2 and has no inhibitory activity against Plk3.

分子式

C₂₁H₂₅NO₈S^.Na

分子量

473.47

CAS号

1225497-78-8

中文名称

N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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浓度

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

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浓度

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Other Forms of Rapamycin:

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The molarity calculator equation

The dilution calculator equation