Methylene Blue (hydrate) - CAS:122965-43-9

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Methylene Blue (hydrate) (Synonyms:亚甲蓝水合物; Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate)

目录号 : KCM10750 CAS No. : 122965-43-9 纯度 : ≥95%

Data Sheet SDS 产品使用指南

Methylene blue is a cationic thiazine dye that has diverse biological activities. It inhibits the catalytic function of inducible and constitutive nitric oxide synthases via oxidation of enzyme-bound ferrous iron. Methylene blue also inhibits monoamine oxidase (MAO) and increases the activity of mitochondrial cytochrome C oxidase (complex IV). In vivo, methylene blue stabilizes systemic circulation without increasing peripheral resistance, decreases lipid peroxidation, and reduces anoxic tissue injury in brain and heart in a porcine model of global ischemia and reperfusion injury. It inhibits MAO activity in brain and reduces the age-related decline in grip strength and spatial memory in old mice when administered in drinking water at a concentration of 250 μM. Methylene blue (15, 30, and 60 mg/kg) also reduces immobility time in the forced swim test in mice, indicating antidepressant-like activity. Methylene blue is commonly used to stain cells and tissues in research.

规格	价格	是否有货
25g		In-stock
50g		In-stock
100g		In-stock
250g	询价	In-stock

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生物活性

Methylene Blue (hydrate) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.

体外研究

Methylene Blue (hydrate) (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA.

体内研究

Methylene Blue (hydrate) (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition.

Methylene Blue (hydrate) (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau.

Methylene Blue (hydrate) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior.

Methylene Blue (hydrate) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor.

Animal Model:	Male NMRI mice
Dosage:	50 and 100 mg/kg
Administration:	Intraperitoneal injection; once, for 25 minutes
Result:	Reduced the prepulse inhibition and reduced the increase in locomotor activity caused by phencyclidine (PCP).

Animal Model:	CaMKIIα-tTA transactivator mice
Dosage:	20 and 40 mg/kg
Administration:	Oral administration; daily, for 6 months
Result:	Inhibited Tau aggregation in CaMKIIα-tTA transactivator mice.

Animal Model:	TBI-treated male BALB/c mice
Dosage:	2 mg/kg
Administration:	Intravenous injection; once, for 1 day
Result:	Decreased the level of CD14, IL-1β, TNF-α, and CCL2 mRNA.

Animal Model:	TBI-treated male BALB/c mice
Dosage:	2 mg/kg
Administration:	Intravenous injection; once, for 1 day
Result:	Reduced the percentage of myeloid (CD11b+/GR1+) cells, reduced IL-1β and enhanced IL10 expression in microglia.

分子式

C₁₆H₁₈N₃S^.Cl^.XH₂O

CAS号

122965-43-9

中文名称

次甲基兰水合物;亚甲基兰

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

DMSO : 7.14 mg/mL (Need ultrasonic)

H2O : 2 mg/mL (ultrasonic and warming and heat to 60°C)

纯度： ≥95%

Data Sheet

SDS

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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