7-oxo Staurosporine - CAS:125035-83-8

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7-oxo Staurosporine (Synonyms:7-氧代星形孢菌素;BMY-41950)

目录号 : KCM10834 CAS No. : 125035-83-8 纯度 : ≥98%

Data Sheet 产品使用指南

7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (ICs = 9, 26, 5, 200, and 800 nM, respectively). 7-oxo Staurosporine induces cell cycle arrest in the G/M phase in human leukemia K562 cells with a minimal effective dose (MED) of 30 ng/ml. It is cytotoxic to P388 mouse leukemia cells that are resistant and susceptible to doxorubicin . 7-oxo Staurosporine inhibits growth of the mycelial, but not yeast form of C. albicans, C. krusei, C. tropicalis, and C. lusitaniae (MICs = 3.1-25 μg/ml). It increases sphingomyelin synthesis in CHO-K1 cells when used at a concentration of 50 nM.

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1mg		In-stock
5mg		In-stock

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生物活性

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.

体外研究

7-Oxostaurosporine (50 nM, 24 h) can lead to an increase in plasma membrane sphingomyelin in CHO cells but does not alter ceramide content.

体内研究

7-Oxostaurosporine (6 mg/kg, once daily, intravenous) significantly reduces tumour growth with a tumour growth inhibition (TGI) of 56.1% and no significant effect on body weigh.

分子式

C₂₈H₂₄N₄O₄

分子量

480.5

CAS号

125035-83-8

中文名称

7-氧代星形孢菌素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

Data Sheet

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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