(±)16-HETE - CAS:128914-46-5

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(±)16-HETE

目录号 : KCM10935 CAS No. : 128914-46-5 纯度 : ≥98%

Data Sheet 产品使用指南

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 µM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.

规格	价格	是否有货	数量
25μg		In-stock
50μg		In-stock
100μg		In-stock

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生物活性

16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease[1].

体外研究

16-HETE (0.01-1 μM) specifically inhibits the aggregation and adhesion of polymorphonuclear leukocytes, but has no significant effect on platelet function and blood pressure [1].

体内研究

16-HETE (1-20 μg, arterial injection) participates stereospecifically (S-enantiomer) in vasodilation, renal perfusion regulation, and tubular transport mechanisms in New Zealand white rabbits [2].
16-HETE (1 μg/kg/min) can inhibit the increase of intracranial pressure (ICP) in the thromboembolic stroke model of New Zealand white rabbits [1].

Animal Model:

New Zealand White rabbit

Dosage:

1-20 μg

Administration:

injection into artery

Result:

16S inhibited 60% ATPase activity at the concentration of 2 μM, while 16R enantiomer remained inactive.

Animal Model:	New Zealand White rabbit
Dosage:	1 μg/kg/min
Administration:	6 hours constant infusion from Hours 1 to 2 after autologous clot embolization
Result:	Reduced infarction area and less increased ICP.

分子式

C₂₀H₃₂O₃

分子量

320.5

CAS号

128914-46-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥98%

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