Lansoprazole sulfone - CAS:131926-99-3

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Lansoprazole sulfone (Synonyms:兰索拉唑砜; AG-1813)

目录号 : KCM11027 CAS No. : 131926-99-3 纯度 : ≥98%

Data Sheet SDS 产品使用指南

Lansoprazole sulfone is a phase I metabolite of lansoprazole. Lansoprazole is a proton pump inhibitor that inactivates the hydrogen/potassium-stimulated ATPase pumps in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH. Lansoprazole is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form lansoprazole sulfone.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
25mg		In-stock
50mg		In-stock
10 mM * 1 mL in DMSO		In-stock

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Other Forms of Rapamycin:

FR-167356 In-stock
Lansoprazole sulfone In-stock
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生物活性

Lansoprazole sulfone, Lansoprazole (KM11094) metabolite, is a H⁺, K⁺-ATPase inhibitor. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease.

体外研究

Lansoprazole sulfone is generated through CYP3A4 mediated sulfidation reaction, and its AUC_0-tratio with Lansoprazole (KM11094) does not show a significant trend with the degree of renal dysfunction or disease course, and there is no accumulation phenomenon relative to Lansoprazole [1].

分子式

C₁₆H₁₄F₃N₃O₃S

分子量

385.36

CAS号

131926-99-3

中文名称

兰索拉唑砜

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

2-8°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO: 250 mg/mL (648.74 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5950 mL	12.9749 mL	25.9498 mL
5 mM	0.5190 mL	2.5950 mL	5.1900 mL
10 mM	0.2595 mL	1.2975 mL	2.5950 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%