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NOC-5
目录号 : KCM11499 CAS No. : 146724-82-5 纯度 : ≥98%
NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH ≥10.0).
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1mg
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5mg
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25mg 询价 In-stock

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生物活性

NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors. NOC-5 is able to increase intracellular XIAP and Aven levels, potentially leading to the inhibition of caspase-9 activity following increased mitochondrial permeability.

体外研究

NOC-5 (5-20 μM) can lead to a rapid increase in NO release on the first day in PBS [1].

NOC-5 (100 μM, 24 hours) only activates caspase-3; After NO donor treatment, caspase-3 activity increased. NOC-5 has a pro apoptotic effect in Jurkat cells, but at the same time increases the level of anti apoptotic proteins.

分子式
C6H16N4O2
分子量
176.2
CAS号
146724-82-5
运输条件

Shipping with dry ice.

储存方式
-80°C
The molarity calculator equation
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2