NOC-5 (5-20 μM) can lead to a rapid increase in NO release on the first day in PBS [1].
NOC-5 (100 μM, 24 hours) only activates caspase-3; After NO donor treatment, caspase-3 activity increased. NOC-5 has a pro apoptotic effect in Jurkat cells, but at the same time increases the level of anti apoptotic proteins.