2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) - CAS:146877-98-7

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2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) (Synonyms:5'-Deoxyguanylic acid disodium hydrate)

目录号 : KCM11504 CAS No. : 146877-98-7 纯度 : ≥95%

Data Sheet 产品使用指南

2'-Deoxyguanosine 5'-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum. In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.

规格	价格	是否有货	数量
500mg		In-stock
1g		In-stock
5g		In-stock

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生物活性	2'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate) is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism).
分子式	C₁₀H₁₂N₅O₇P^.₂Na[XH₂O]
CAS号	146877-98-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)