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  3. Metabolic Enzyme/Protease | 代谢酶/蛋白酶
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S-NEPC (Synonyms:4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate)
目录号 : KCM11512 CAS No. : 147349-28-8 纯度 : ≥98%
Data Sheet 产品使用指南
Cytochrome P450 metabolites of arachidonic acid, such as 11(12)-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.
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生物活性

S-NEPC is a colorimetric substrate used to measure epoxide hydrolase activity.
分子式
C16H13NO6
分子量
315.3
CAS号
147349-28-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C

3 years
In solvent -80°C 6 months
  -20°C 1 month
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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