NE 100 - CAS:149409-57-4

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NE 100 (Synonyms:NE 100 hydrochloride;N,N-二乙基-2-(4-甲氧基-3-苯乙基氧基苯基)乙胺盐酸盐)

目录号 : KCM11557 CAS No. : 149409-57-4 纯度 : ≥98%

Data Sheet SDS 产品使用指南

NE 100 is a potent antagonist of sigma-1 (σ) receptors (IC = 4.16 nM). It only weakly antagonizes dopamine, serotonin, and PCP receptors, but may indirectly alter receptor activity through its effects on σ NE 100 is commonly used to study the role of σ receptor signaling in cells or animals.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock
10 mM * 1 mL in Water		In-stock

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Other Forms of Rapamycin:

NE 100 In-stock
Ceapin-A7 In-stock
AA147 In-stock

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生物活性

NE 100 （NE 100 hydrochloride） is an orally active and selective sigma-1 receptor antagonist with an IC₅₀ of 4.16 nM. NE 100 （NE 100 hydrochloride） can improve cognitive impairment and has neuroprotective and antipsychotic activities. NE 100 （NE 100 hydrochloride） can be used for research on nervous system diseases.

体外研究

NE 100 (0.1-3 µM; 1-25 h) can inhibit cell death and regulate the expression of endoplasmic reticulum stress-related proteins in HT22 cells treated with Tunicamycin. The mechanism involves activation of the ATF6 pathway [1].

Western Blot Analysis

Cell Line:	Tunicamycin treated HT22 cells
Concentration:	3 µM
Incubation Time:	Pretreated with 1 h, then co-incubation for 24 h
Result:	Inhibited the protein level of CHOP.

体内研究

NE 100 (oral; Single dose) has antipsychotic activity in rats.
NE 100 (0.03-1 mg/kg; oral administration; Single dose Hydrochloride has an improving effect in a rat model of cognitive impairment.

Animal Model:	Male Wistar rats (80-120 g) treated (+)SKF10047 or phencyclidine to induce head-weaving behavior model
Dosage:
Administration:	Oral administration; single dose
Result:	Dose-dependently antagonized (+)SKF10047 (HY-101376) or phencyclidine induced head-weaving behavior with oral ED₅₀ at 0.27 and 0.12 mg/kg, respectively.

Animal Model:	Male Wistar rats (~250 g) treated phencyclidine to induce delayed cognitive dysfunction
Dosage:	0.03, 0.1 and 0.3 mg/kg (before the first trial of the water maze test) 0.1, 0.3 and 1 mg/kg (after phencyclidine injection)
Administration:	Oral administration; single dose
Result:	Significantly and dose-dependently reduced the escape latency of rats in the water maze task, indicating improvement of phencyclidine-induced delayed cognitive dysfunction. Had lower effective doses when administered before the trial (late intervention) compared to administration after phencyclidine injection (early intervention).

分子式

C₂₃H₃₃NO₂^.HCl

分子量

391.97

CAS号

149409-57-4

中文名称

N,N-二乙基-2-(4-甲氧基-3-苯乙基氧基苯基)乙胺盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H2O : ≥ 100 mg/mL (255.12 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5512 mL	12.7561 mL	25.5122 mL
5 mM	0.5102 mL	2.5512 mL	5.1024 mL
10 mM	0.2551 mL	1.2756 mL	2.5512 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%