FTase Inhibitor I - CAS:149759-96-6

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FTase Inhibitor I (Synonyms:B581)

目录号 : KCM11567 CAS No. : 149759-96-6 纯度 : ≥95%

Data Sheet SDS 产品使用指南

FTase inhibitor I is a potent inhibitor of farnesyltransferase (FTase; IC = 21 nM) that is greater than 30-fold selective for FTase over geranylgeranyl transferase (GGTase; IC = 790 nM). It prevents farnesylation of Ras and inhibits proliferation of cells transformed by Ras farnesylation. In a dog model of subarachnoid hemorrhage, it reduces GTP-Ras in spastic basilar arteries, decreases angiographic vasospasm, and improves clinical scores.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock

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生物活性

Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras).

体外研究

Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar.

分子式

C₂₂H₃₈N₄O₃S₂

分子量

470.7

CAS号

149759-96-6

中文名称

N-[(2S)-((2R)-2-氨基-3-巯基丙基氨基)-3-甲基丁基]-L-苯丙氨酰-L-蛋氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： ≥95%

Data Sheet

SDS

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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