5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties. It is cytotoxic to KB, A549, and HCT-8 cells (ECs = 2.9, 3.1, and 2.5 µg/ml, respectively). It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1 (ICs = 10.4 and 5.1 µg/ml, respectively). However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.
5-Methoxycanthinone is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC50 of 5.44 μg/mL against Ailanthus altissima cells.
分子式
C15H10N2O2
分子量
250.25
CAS号
15071-56-4
中文名称
5-甲氧基铁屎米酮
运输条件
Room temperature in continental US; may vary elsewhere.