Emtricitabine S-oxide - CAS:152128-77-3

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Emtricitabine S-oxide (Synonyms:恩曲他滨 S-氧化物;Emtricitabine sulfoxide; Emtricitabine Degradant-III)

目录号 : KCM11608 CAS No. : 152128-77-3 纯度 : 90%

Data Sheet SDS 产品使用指南

Emtricitabine S-oxide is a potential impurity found in commercial preparations of emtricitabine. Emtricitabine is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity. It inhibits replication of HIV-1 (ECs = 10-20 nM) and hepatitis B (ECs = 10-40 nM) in various cell lines. Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes. In vivo, emtricitabine (3-30 mg/kg) reduces viremia and hepatic woodchuck hepatitis virus (WHV) replication in a dose-dependent manner in a woodchuck model of chronic WHV infection. Formulations containing emtricitabine have been used in the treatment of HIV infection.

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock
10mg		In-stock

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生物活性

Emtricitabine S-oxide is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.

体外研究

Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III).

分子式

C₈H₁₀FN₃O₄S

分子量

263.25

CAS号

152128-77-3

中文名称

恩曲他滨 S-氧化物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 90%

Data Sheet

SDS

产品使用指南

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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