L-Methionine-(S,R)-Sulfoximine - CAS:15985-39-4

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L-Methionine-(S,R)-Sulfoximine (Synonyms:L-蛋氨酸磺酸盐;MSX; MSO)

目录号 : KCM11760 CAS No. : 15985-39-4 纯度 : ≥95%

Data Sheet SDS 产品使用指南

L-Methionine-(S,R)-sulfoximine is an inhibitor of glutamine synthetase and a sulfoximine derivative of L-methionine. It inhibits pea glutamine synthetase by 31 to 64% when used at concentrations ranging from 5 to 25 µM following preincubation with L-glutamine, an effect that is absent without L-glutamine preincubation. It also inhibits glutamine synthetase in isolated chick embryo retinas.

规格	价格	是否有货	数量
10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
10 mM * 1 mL in Water		In-stock

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生物活性

L-Methionine-(S,R)-Sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-(S,R)-Sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-(S,R)-Sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-(S,R)-Sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS).

体内研究

L-Methionine - (S, R) - Sulfoximine (75 mg/kg, intraperitoneal injection, 210 minutes) had no effect on hippocampal glutamine synthetase (GS) activity and GS protein expression in rats during the first 150 minutes, but significantly reduced GS activity during the last 165-210 minutes. In addition, L-Methionine - (S, R) - Sulfoximine also reduced the intensity of seizures (CS) and epileptic seizures induced by administration of pilo in rats.
L-Methionine - (S, R) - Sulfoximine (75 mg/kg, intraperitoneal injection) reduced K+- induced depolarization induced D-Asp release and maintained unchanged glutamate uptake in the hippocampus and endometrial cortex of rats with temporal lobe epilepsy (TLE) model.

Animal Model:	Male rats (24 days old, Sprague Dawley)
Dosage:	75 mg/kg
Administration:	210 min, i.p., measurements were taken at MSO “0”, after 15 min (referred to as MSO “15”, Pilo “15” and MSO + Pilo “15”) and after 60 min (MSO “60”, Pilo “60” and MSO + Pilo “60”, respectively
Result:	Did not affect the hippocampal GS activity and the expression of GS protein for the first 150 min, but significantly decreased the activity during 165-210 min after MSO administration in rats. Additionally, MSO reduced the intensity of CS caused by Pilo administration.

Animal Model:	Hippocampus and enthorhinal cortex of TLE model rats
Dosage:	75 mg/kg
Administration:	i.p., Administration 150 minutes before decapitation
Result:	Markedly reduced D-Asp release evoked by K⁺-induced depolarization and slightly decreased [³H]D-Asp uptake at higher concentrations of [³H]D-Asp in TLE model rats.

分子式

C₅H₁₂N₂O₃S

分子量

180.23

CAS号

15985-39-4

中文名称

L-蛋氨酸磺酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 50 mg/mL (277.42 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5485 mL	27.7423 mL	55.4847 mL
5 mM	1.1097 mL	5.5485 mL	11.0969 mL
10 mM	0.5548 mL	2.7742 mL	5.5485 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS

Solubility: 100 mg/mL (554.85 mM); Clear solution; Need ultrasonic

纯度： ≥95%

Data Sheet

SDS

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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体积

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

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Other Forms of Rapamycin:

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The molarity calculator equation

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