(±)-Epibatidine (hydrochloride) - CAS:162885-01-0

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(±)-Epibatidine (hydrochloride) (Synonyms:(±)-地棘蛙素;CMI 545 dihydrochloride;(±)-Epibatidine dihydrochloride)

目录号 : KCM11831 CAS No. : 162885-01-0 纯度 : ≥98%

Data Sheet 产品使用指南

(±)-Epibatidine is an alkaloid that has been found in Ecuadoran poison frog (E. tricolor) skin extracts and an agonist of α4β2 subunit-containing nicotinic acetylcholine receptors (nAChRs; K = 43 pM). It is selective for α4β2 subunit-containing nAChRs over α7 nAChRs (K = 230 nM). (±)-Epibatidine enhances Rb flux in IMR-32 cells (EC = 7 nM) and induces dopamine release from rat striatal slices (EC = 0.4 nM), effects that can be reduced by the nAChR antagonist mecamylamine . In vivo, (±)-epibatidine induces analgesia in the hot plate test and the Straub-tail response in mice (EDs = 0.005 and 0.02 mg/kg, respectively).

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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生物活性	(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors.
分子式	C₁₁H₁₃ClN₂^.₂HCl
分子量	281.61
CAS号	162885-01-0
中文名称	(±)-地棘蛙素;rel-(1R,2R,4S)-2-(6-氯-3-吡啶基)-7-氮杂双环[2.2.1]庚烷二盐酸盐
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)