Immepip is a histamine H receptor agonist (K = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H over H and H receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Ks = >16 μM for both) but also agonizes H receptors (K = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.
Immepip (hydrobromide) is a H3 agonist. Immepip (hydrobromide) can reduce cortical histamine release. Immepip (hydrobromide) can be used for the research of neurological diseases.
体外研究
Immepp (hydrobromide) (intraperitoneal injection; 5 mg/kg, 10 mg/kg) significantly reduced cortical histamine release and weakly promoted sleep in rats.
分子式
C9H15N3.2HBr
分子量
327.06
CAS号
164391-47-3
中文名称
4-(1H-咪唑基-4-甲基)哌啶二氢溴酸盐
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
2-8°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:
H2O : ≥ 125 mg/mL (382.19 mM)
* "≥" means soluble, but saturation unknown.
配制储备液
浓度溶剂体积质量
1 mg
5 mg
10 mg
1 mM
3.0575 mL
15.2877 mL
30.5754 mL
5 mM
0.6115 mL
3.0575 mL
6.1151 mL
10 mM
0.3058 mL
1.5288 mL
3.0575 mL
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。