Terpendole I
目录号 : KCM11913 CAS No. : 167612-17-1 纯度 : ≥95%
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis. It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC = 145 µM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 µg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 µg/ml for all) or the fungus C. albicans (MIC = 200 µg/ml). It is cytotoxic to HeLa cells with an IC value of 52.6 µM.
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1mg
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5mg
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生物活性

Terpendole I is a fungal indole diterpenoid and an ACAT inhibitor (IC50 = 145 µM). Terpendole I can be used in studies related to lipid metabolism.

体外研究

Terpenpole I can weakly inhibit ACAT activity in rat liver microsomes, with an IC50 of 145 μM.
Terpendole I (1 mg/mL (10 μg/paper disk); 24 hours (bacteria); 48 hours (fungi, yeast) showed no antibacterial activity against the tested bacteria, fungi, and yeast.

分子式
C27H35NO5
分子量
453.57
CAS号
167612-17-1
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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