Reversin 121 - CAS:174630-04-7

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Reversin 121

目录号 : KCM11990 CAS No. : 174630-04-7 纯度 : ≥98%

Data Sheet 产品使用指南

Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a K value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells.

规格	价格	是否有货	数量
500μg		In-stock
1mg		In-stock
5mg		In-stock

加入购物车大包装询价

Other Forms of Rapamycin:

MCT1-IN-3 In-stock
HM-30181 mesylate monohydrate In-stock
Pepluanin A In-stock
Jatrophane 5 In-stock
Reversin 121 In-stock

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生物活性

Reversin 121 is a P-glycoprotein inhibitor. Reversin 121 increases the ATPase activity of MDR1. Reversin 121 reverses P-glycoprotein-mediated multidrug resistance. Reversin 121 can be used in the research of cancers.

体外研究

Reversin 121 (12 μg/mL) (with gemcitabine) reduces the proportions of tumor cells positive for MDR proteins in Panc1 cell.
Reversin 121 (5 μM) reverses the resistance against paclitaxel in paclitaxel-resistant NCI-H460 cell.
Reversin 121 (10 μM, 48 h) inhibits T cell proliferation.

体内研究

Reversin 121 (2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day, i.p.) decreases tumor size and prevalence of metastases.

Animal Model:	Orthotopic pancreatic carcinoma mouse model
Dosage:	2.5 mg/kg, plus 5-fluorouracil, 35 mg/kg/day
Administration:	Intraperitoneal injection (i.p.), 5 days a week
Result:	Decreased in MRP3-positive cells.

分子式

C₃₄H₄₇N₃O₉

分子量

641.75

CAS号

174630-04-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO: 100 mg/mL (155.82 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.5582 mL	7.7912 mL	15.5824 mL
5 mM	0.3116 mL	1.5582 mL	3.1165 mL
10 mM	0.1558 mL	0.7791 mL	1.5582 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥98%